Our Compounding Lab – A Brief Virtual Tour

We recently completed a renovation project to more than double the size of our compounding lab.  Until now, we were doing some compounding in a small lab that was shared by our four glove Microsphere®, a positive flow, isolation chamber also known as a “glove box”, for the preparation of sterile preparations.  Here is a quick tour of our lab to see just what kind of facility, equipment and resources are necessary to make custom compounded preparations possible in the community.

Although the construction crews have left and the electricians and plumbers have collected their tools, we are still outfitting the lab with equipment, instruments and technology that will allow the pharmacists and technicians the ability to prepare all manner of innovative dosage forms to better solve the many therapeutic problems that we are presented each day.   The expansion resulted in a doubling of workspace, a new cleaning station that includes a lab quality glass washer, a new home for our powders hood (Safe AiRx), new expanded chemical storage and larger chemical inventory, technicians workstation, mixing station (for Unguators and Ointment Mill), new three glove Microsphere Isolation Hood and ample work area for pharmacists and technicians.

 

Click on any image to enlarge the view

A new entry to the lab that is visible to anyone in the pharmacy. On the immediate left of the entry is the new lab area with ample counter space for prep work and a powder hood where all powder manipulations of active principles are done. All new clean up station including a Miele Lab glass washer that will leave glassware analytically clean. Not all instruments and equipment can survive the wash and rinse cycles that are used on some of the wash programs.
We now have ample room for chemical storage allowing us to not only inventory the stock so it can be quickly found but also allow for the addition of new items as we continue to expand our compounding abilities. We’ve made sure the pharmacists and technicians have access to our information network both internet and intranet. This workstation gives access to all the information tools in use in the dispensary plus the reference sources for compounding such as the PCCA members only site and access to our own customized compounding database program. The majority of the chemical powder manipulations are done within a Safe AiRx hood made my Isotech Design, a Canadian company. Many of the active principles being manipulated are potent drugs or hormones that have their own pharmacologic action at mcg or mg dosages. Therefore when a technician is making mg or gm transfers of the powders, their safety is a priority.
Microsphere gauges panel displaying the operational performance of the hood while in operation.Unlike traditional horizontal laminar flow hoods, the MicroSphere provides an enclosed work area with a pre-chamber for the safe transfer of supplies & preparation ingredients.  The work area is never open to the surrounding environment. Full front view of the Microsphere three glove unit before use. The Microsphere hood must be in operation for a minimum of 30 minutes before use. This allows the interior environment to reach an equilibrium that ensures the optimal laminar air flow which is needed to protect the item being prepared in the aseptic (~sterile) confines of the hood. A technician is doing all manipulations through gloves attached to the front face of the Microsphere. The positive pressure produced by the laminar air flow causes the sleeves to bellow out. This “outward” flow of laminar air (“columns of air”) is what protects the preparation and all the ingredients being used from by bacterial, viral or chemical contamination.

 

Our thanks to those companies and individuals who provided services and expertise for the Wesbridge Construction the general contractor, Ian Mukaida of Quarter Circle Retail Management , Wil-Sand Custom Woodwork, Rieve Plumbing, Coleman Electric, South-Alta Communications, Miele Canada, PCCA Canada and Isotech Design.

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